If you are found to have testosterone deficiency syndrome, this treatment might be suitable for you. Nebid0® is an intramuscularly administered depot preparation of testosterone undecanoate. One ampoule of the substance contains 1000 mg of testosterone undecanoate in 4ml of oily based solution. An increase in serum levels of testosterone above basal values may be seen immediately after administration and peak levels will be achieved in 1 week time. The drug is formulated to allow sustained release of testosterone into the systemic circulation once injected into the muscle. The muscle serves as a depot and therefore each injection will last up to 14 weeks in duration, making the testosterone replacement therapy a lot more convenient and affordable. This treatment is administered via injection in intervals of 10-14 weeks.
It is advisable to reduce the first interval to six weeks in order to reduce the time until steady state conditions are reached. Individualisation of therapy is required and should be based on serum testosterone levels achieved under this treatment and clinical symptomatology. Your progress will be monitored and we will find out the most optimum duration between injections, specifically for you. As an injection it does not cause skin sensitivity like testosterone patches or gels and its resorption has no dependency on food intake like oral forms of testosterone. As a consequence of the restoration of testosterone levels, research has confirmed significant improvements of symptoms associated with testosterone deficiency after the injections.
Pharmacokinetic studies showed that TRT with this treatment maintains testosterone levels within the therapeutic range, therefore minimising side effects associated with supra-physiological level. The recommended administration regime consists of one loading dose 6 weeks after the initial injection followed by intervals of 10 to 14 weeks. Most patients will achieve a normal testosterone range within 2-3 consecutive injections. The most frequent side effect is injection site tenderness; this usually lasts only for 48 hours. Development of acnes is a possibility but usually mild and transient. Other side effects that would be monitored throughout your TRT are increased in blood count, changes in cholesterol profile, increased PSA levels, and symptoms of prostatism. Your full blood count, PSA, liver function test, cholesterol levels will be checked periodically to minimise the risk of complication.
Like every adrogen therapy, the use of TRT is contraindicated in diagnosed and suspected carcinoma of the prostate or of the male mammary gland, past and present liver tumours and hypersensitivity to the active substance or to any of the excipients. Nebid0® is not licensed in those less than 18 years of age. Besides this, other commonly prescribed intramuscular testosterone injections are Testosterone Enantat3, Sustan0n-250® and Vir0rm0ne®. These testosterone injections can be offered as an alternative. Nonetheless, due to their shorter duration of action, injection frequency is markedly increased, same for the associated cost. Testosterone Enantate; 250mg/ml, maintenance every 3-6 weeks Sustanon-250®; testosterone proprionate 30mg, testosterone phenylpropionate 60mg, testosterone isocaproate 60mg and testosterone decanoate 100mg/ml; maintenance every 3 weeks Virormone®; testosterone propionate 50mg/ml, maintenance 2-3 times weekly.